The following collections, comprising over 9.4 Million documents, are now available in ToxPlanet.
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ACuteTox set the very ambitious overall objective of developing an in vitro test strategy sufficiently robust and powerful to completely replace in vivo testing of acute toxicity of chemicals. The main objectives of the project included the compilation, evaluation and generation of high quality in vitro and in vivo data on a set of reference chemicals for comparative analyses, and the identification of factors that influence the correlation between in vitro (concentration) and in vivo (dose) toxicity, particularly taking into consideration biokinetics, metabolism and organ toxicity (liver, central nervous system, kidney). This collection comprises the work product of 97 reference chemicals.
AGRITOX is a French database created in 1986 by the National Institute for Agricultural Research on physico-chemical properties, toxicity, ecotoxicity, fate and behaviour in the environment and regulatory data on pesticides active substances. Only data judged valid by experts from official bodies in charge of the evaluation at national and/or European levels are presented, the sources of the data are the dossiers submitted by industry and published scientific literature.
American Botanical Council - Commission E Monographs
This collection contains all monographs published by Commission E between 1983 and 1995, including all revisions (incorporated into the monographs). It also includes extensive indexes of therapeutic data (uses, contraindications, side effects, drug interactions, etc.), plus chemical and taxonomic cross-references (English, Latin, German, and pharmacopeial names), excerpts from European regulatory literature, glossary of terms, and general index.
American Botanical Council - Herbal Medicine: Expanded Commission E
This well referenced, instructive, and clinically accurate guide provides everything you need to know about the safe and effective use of medicinal herbs. Published by the American Botanical Council (ABC), the book contains comprehensive, scientifically based information on 29 herbs and 13 proprietary herbal products.
American Herbal Products Association (AHPA) Botanical Identity References Compendium
Developed and maintained by the American Herbal Products Association (AHPA), the AHPA Botanical Identity References Compendium is a centralized source of information on physical characteristics and test methods that can be used to determine the identity of plant species and articles of trade obtained from these plants. Botanical species covered include commercially available herbs, plant materials known to be subject to misidentification, and species that are common in various traditional herbal disciplines. With its diverse and detailed information, the AHPA Botanical Identity References Compendium provides a useful resource for botanical researchers, professionals involved with the manufacture of herbal products, and many others.
AromaDb database is a library of aroma molecules of medicinal and aromatic plants origin and include the comprehensive information about aroma plants, varieties, accessions, chemotypes, essential oils yields, chromatograms, major and minor compounds, structural elucidation data, structural data (2D & 3D) of very small size volatile molecules (< 300 mol. wt.) and medium size molecules (< 500 mol. wt.), and biological pathways information.
ASEAN – Japan Chemical Safety Database
The ASEAN – Japan Chemical Safety Database (AJCSD) is developed by ASEAN countries and Japan under AMEICC Working Group on Chemical Industry that consists of representatives from ASEAN countries and JAPAN. The AJCSD includes chemical regulatory information, GHS classification results, risk and hazard information, etc. The purpose of AJCSD is to enhance transparency and to reduce compliance risk and improve chemical safety in the ASEAN countries.
ATSDR Interaction Profiles
The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) mandates that the Agency for Toxic Substances and Disease Registry (ATSDR) shall assess whether adequate information on health effects is available for the priority hazardous substances. The Act further directs that where feasible, ATSDR shall develop methods to determine the health effects of substances in combination with other substances with which they are commonly found. To carry out these legislative mandates, ATSDR’s Division of Toxicology (DT) has developed a guidance manual that outlines the latest methods for mixtures assessment. In addition, a series of documents called Interaction Profiles are being developed for certain priority mixtures that are of special concern to ATSDR. The purpose of the Interaction Profile is to evaluate data on the toxicology of the ‘whole’ priority mixture (if available) and on the joint toxic action of the chemicals in the mixture in order to recommend approaches for the exposure-based assessment of the potential hazard to public health.
ATSDR Medical Management Guidelines (MMGs)
The Medical Management Guidelines (MMGs) for Acute Chemical Exposures were developed by ATSDR to aid emergency department physicians and other emergency healthcare professionals who manage acute exposures resulting from chemical incidents. The MMGs are intended to aid healthcare professionals involved in emergency response to effectively decontaminate patients, protect themselves and others from contamination, communicate with other involved personnel, efficiently transport patients to a medical facility, and provide competent medical evaluation and treatment to exposed persons.
ATSDR Public Health Statements (English & Spanish)
The ATSDR Public Health Statements (PHSs) are a series of summaries about hazardous substances developed by the ATSDR Division of Toxicology. The information in these PHSs has been taken from Chapter One of their respective ATSDR Toxicological Profiles. Each Public Health Statement serves as a summary for that complete Toxicological Profile. The PHSs provide information in a question and answer format which address the most frequently asked questions about exposure to hazardous substances found around hazardous waste sites and the effects of exposure on human health.
ATSDR Spanish ToxFAQs™
Same as ATSDR ToxFAQs, written in Spanish.
ATSDR Substance-Specific Priority Data Needs (PDN)
The ATSDR’s congressionally-mandated Substance-Specific Applied Research Program (SSARP) consists of a research agenda for priority hazardous substances. In establishing the SSARP, ATSDR first identifies data needs in its Toxicological Profiles for these substances. The data needs are then subjected to further evaluation and prioritized using the Agency’s Decision Guide. The priority data needs represent essential information to improve the database for conducting public health assessments. The identified priority data needs reflect the opinion of ATSDR, in consultation with other federal programs.
The ATSDR ToxFAQs is a series of summaries about hazardous substances developed by the ATSDR Division of Toxicology. Information for this series is excerpted from the ATSDR Toxicological Profiles and Public Health Statements. Each fact sheet serves as a quick and easy to understand guide. Answers are provided to the most frequently asked questions (FAQs) about exposure to hazardous substances found around hazardous waste sites and the effects of exposure on human health.
ATSDR ToxFAQs™ Chemical Agent Briefing Sheets (CABS)
The ToxFAQs™ CABS provide current and relevant scientific information on specific high-profile chemicals for public officials, business leaders, concerned citizens, and others to use in their work. The series presents a detailed overview of high-profile hazardous materials that people may encounter during daily activities. The information provided in the ToxFAQs™ CABS can facilitate factual review and public discussion about these chemicals so that appropriate protective actions and potential research can be considered or undertaken to safeguard the physical environment and the public’s health.
ATSDR Toxicological Profiles
By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces “toxicological profiles” for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.
Australian Government – Department of Health – National Industrial Chemicals Notification and Assessment Scheme (NICNAS) – IMAP Assessments
The IMAP (Inventory Multi-tiered Assessment and Prioritisation) Framework is a science- and risk-based model designed to align the assessment effort with the human health and environmental impacts of chemicals. It has three tiers of assessment, with the assessment effort increasing with each tier. A decision is made at the end of each assessment tier if the next tier of assessment is required to determine risk. The risk assessments for human health and environment have been conducted separately and may have different outcomes and be published separately. The assessment outcomes are based on the information available at the time.
Australian Government – Department of Health – National Industrial Chemicals Notification and Assessment Scheme (NICNAS) – Priority Existing Chemical (PEC) Assessments
A Priority Existing Chemical (PEC) is an industrial chemical that has been identified as requiring an assessment because there are reasonable grounds for believing that manufacturing, handling, storing, using or disposing of the chemical could be a risk to health and/or the environment. This collection contains the assessments for the ~100 chemical assessed since the program’s inception.
Berufsgenossenschaft Rohstoffe und Chemische Industrie (BG RCI) – Toxicological Evaluations
The former BG Chemie (after 2010 its legal successor is Berufsgenossenschaft Rohstoffe und Chemische Industrie (BG RCI)) has published Toxicological Evaluations for 245 industrial chemicals. The reports are available in German (as full-length or short version) and in English (full-length).
Biodegradation Literature References (BIOLOG)
BIOLOG was developed through the collaborative efforts of the EPA’s Office of Toxic Substances and the Syracuse Research Corporation (SRC). BIOLOG is an index of published literature covering biodegradation of chemical substances, and microbial toxicity (the toxicity of chemical substances to microbial populations). Over 62,600 records cover more than 7,850 different chemicals.
Biodegradation of Substances in the Environment (BIODEG)
BIODEG was developed through the collaborative efforts of the EPA’s Office of Toxic Substances and the Syracuse Research Corporation (SRC). This database includes over 6,600 records with information about the biodegradation of 815 chemical substances in several types of experiments (biological treatment simulations, screening tests, field studies, grab sample tests, etc.) under a variety of experimental conditions (e.g., aerobic, anaerobic).
California EPA Air Resources Board (ARB) – Fact Sheets
Fact sheets on general exposure and health effects information for the substances included on California’s 1996 Toxic Air Contaminant Identification List.
California EPA Air Resources Board (ARB) – Toxic Air Contaminant (TAC) Identification Reports
The ARB prepares identification reports on candidate substances under consideration for listing as toxic air contaminants under Assembly Bill 1807 (AB 1807) (Stats. 1983, Ch. 1047; Health and Safety Code section 39650 et seq., Food and Agriculture Code Section 14021 et seq.). The reports and summaries describe the uses of and the extent of emissions in California resulting in public exposure, together with their potential health effects.
California EPA Department of Pesticide Regulation (DPR) – Toxicology Data Review Summaries
Published by the California Environmental Protection Agency Department of Pesticide Regulation Medical Toxicology Branch, this collection contains summaries of toxicology data on over 500 chemicals and pesticides commonly used in California.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Acute Reference Exposure Levels (ARELs)
Summaries on individual chemicals having Acute Reference Exposure Levels developed by OEHHA.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Chemical Database
The OEHHA Chemical Database is a compilation of health hazard information developed by OEHHA, including reference exposure levels, California public health goals, child specific reference doses, Proposition 65 safe harbor numbers, soil-screening levels, and fish advisories.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Child-Specific Reference Doses (chRDs)
Child-specific reference doses (chRDs) are numerical health guidance values developed by the Office of Environmental Health Hazard Assessment (OEHHA) on behalf of the California Environmental Protection Agency, pursuant to Health and Safety Code Sections 901(f) and 901(g). ChRDs were developed in response to the increasing evidence that children are more sensitive to the effects of some toxic chemicals than adults and to address the growing concern that existing Reference Doses (RfDs) may not adequately account for this increased sensitivity. ChRDs and associated guidance is intended to assess exposure and health risk at existing and proposed school sites, including child-specific routes of exposure unique to the school environment.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Chronic Reference Exposure Levels (CRELs)
Summaries on individual chemicals having Chronic Reference Exposure Levels developed by OEHHA.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Public Health Goals
Under California Law, OEHHA develops and adopts Public Health Goals (PHGs) for chemicals in drinking water. PHGs are to be based on risk assessments conducted using “most current principles, practices, and methods used by public health professionals” and certain public health criteria. OEHHA is required to develop and adopt PHGs for drinking water contaminants for which there already is a primary drinking water standard (maximum contaminant level, or MCL) as well as for any newly regulated contaminants. PHGs are solely health based; the evaluations and estimated safe levels provide information to the California Department of Health Services as to whether any changes might be appropriate in state MCLs based on the most recent toxicity data and risk assessment methods.
California EPA Office of Environmental Health Hazard Assessment (OEHHA) – Reports
Hazard Identification Documents written in support of California’s Proposition 65 Program.
Canadian Poisonous Plants Information System
The Canadian Poisonous Plants Information System presents data on plants that cause poisoning in livestock, pets, and humans. The plants include native, introduced, and cultivated outdoor plants as well as indoor plants that are found in Canada. Some food and herbal plants are also included that may cause potential poisoning problems.
Carcinogenic Potency Database (CPDB)
Published by the U.S. Department of Energy – Lawrence Berkeley National Laboratory, the CPDB is a widely used resource on the results of chronic, long-term animal cancer tests. It provides a single, standardized and easily accessible database that includes sufficient information on each experiment to permit investigations into many research areas of carcinogenesis. Both qualitative and quantitative information on positive and negative experiments are given, including all bioassays from the National Cancer Institute/National Toxicology Program (NCI/NTP) and results from the general literature that meet a set of inclusion criteria. Analyses of over 6.500 experiments on over 1,500 chemicals are presented. For each experiment, information is included on the species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; histopathology and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response curve; author’s opinion as to carcinogenicity; and literature citation.
Centers for Disease Control (CDC) – Emergency Preparedness & Response
Designed for emergency responders, clinicians, and public health practitioners, this collection provides information on emergency response procedures and public health protocols for incidents involving chemical and bioterrorism agents/diseases.
Chemical Carcinogenesis Research Information System (CCRIS)
CCRIS is a toxicology data file of the National Library of Medicine’s (NLM) Toxicology Data Network (TOXNET®). It is a scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains over 9,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primary journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis.
Chemical Classification and Information Database (CCID)
Produced by the Environmental Protection Authority of New Zealand, the Chemical Classification and Information Database (CCID) contains classifications using the Hazardous Substances and New Organisms (HSNO) Act hazard classification system for single chemicals and includes supporting data when available, including references. The information in the CCID is useful when classifying formulated products or preparing labels and (M)SDS. The HSNO hazard classification system is similar to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals. CCID includes information on over 6,000 substances.
Chemical Entities of Biological Interest (ChEBI)
Produced by the European Bioinformatics Institute (EMBL-EBI), Chemical Entities of Biological Interest (ChEBI) is a dictionary of molecular entities focused on ‘small’ chemical compounds. The term ‘molecular entity’ refers to any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity. The molecular entities in question are either products of nature or synthetic products used to intervene in the processes of living organisms.
Chemical Hazard Response Information System (CHRIS)
Produced by the U.S. Coast Guard, Chemical Hazard Response Information System (CHRIS) is designed to provide information need for decision-making by responsible Emergency Response personnel during emergencies that occur during the water transport of hazardous chemicals. It also provides information that can be used to design safety procedures aimed at preventing emergency situations. While geared toward chemicals transported over water, this information can be useful for a wide range of chemical emergency situations.
chemsec SIN List
The SIN (Substitute it Now!) List is a globally used database of chemicals likely to be banned or restricted in a near future. The chemicals on the SIN List have been identified by ChemSec (The International Chemical Secretariat) as Substances of Very High Concern (SVHC) based on the criteria established by the EU chemicals regulation REACH.
ChemSpider, owned by the Royal Society of Chemistry, is a chemical structure database providing access to structures, properties, and associated information. It integrates and links data from ~480 data sources.
Chinese Herbs & Co. Database
Chinese Herbs & Co. is a reference guide for popular Chinese herbs and other herbal supplements known to build and strengthen the body. Numerous herbs, supplements, and relevant health conditions are covered within this resource. By using the Chinese Herbs & Co. database, users can gain access to valuable information on various plants, their traditional usage, their place in modern medicine, the range of their activity, as well as the risks associated with using them.
Classification and Labelling Inventory (C&L Inventory)
This database contains classification and labelling information on notified and registered substances received from manufacturers and importers. It also includes the list of harmonised classifications. The database is refreshed regularly with new and updated notifications.
ClassyFire is a web-based application for automated rule-based structural classification of chemical entities (including peptide and nucleotide sequences). The system automatically provides a hierarchical chemical classification for all known chemical compounds (including small molecules, peptides and peptide sequences), as well as a structure-based textual description.
Codex Alimentarius - General Standard for Food Additives (GSFA)
The "Codex General Standard for Food Additives" (GSFA, Codex STAN 192-1995) sets forth the conditions under which permitted food additives may be used in all foods, whether or not they have previously been standardized by Codex. The Preamble of the GSFA contains additional information for interpreting the data. Users are encouraged to consult the Preamble when using this database.
Codex Alimentarius - Pesticides Residues in Food
This database contains Codex Maximum Residue Limits for Pesticides and Extraneous Maximum Residue Limits adopted by the Codex Alimentarius Commission up to and including its 39th Session (July 2016).
Codex Alimentarius - Veterinary Drug Residue in Food
This database contains information on Maximum Residue Limits (MRLs) and Risk Management Recommendations (RMRs) for residue of a veterinary drugs in foods.
Collaborative on Health and the Environment (CHE) Toxicant and Disease Database
The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and more than 200 human diseases or conditions. Focusing primarily on human epidemiological studies, the database reflects knowledge about toxicants and disease, organized by disease categories.
Comparative Toxicogenomics Database (CTD)
CTD is a robust, publicly available database that aims to advance understanding about how environmental exposures affect human health. It provides manually-curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are integrated with functional and pathway data to aid in development of hypotheses about the mechanisms underlying environmentally-influenced diseases.
Compendium of Pesticide Common Names
This compendium provides details of the status of all pesticide common names, together with their systematic chemical names, molecular formulae, structural formulae and CAS Registry Numbers®. The Compendium is updated each time that new common names are provisionally approved, and whenever names are finally approved and published in a standard or an amendment.
Concawe was established in 1963 by a small group of leading oil companies to carry out research on environmental issues relevant to the oil industry. Its membership has broadened to include most oil companies operating in Europe. The scope of Concawe’s activities has gradually expanded and it now publishes detailed reports on areas such as fuels quality and emissions, air quality, water quality, soil contamination, waste, occupational health and safety, petroleum product stewardship and cross-country pipeline performance.
Cosmetics to Optimise Safety (COSMOS) – Threshold of Toxicological Concern
The Threshold of Toxicological Concern (TTC) is a widely applied risk assessment approach that establishes a human exposure threshold value for chemicals, below which there is a low probability of an appreciable risk to human health. This dataset contains repeated dose toxicity data for cosmetic ingredients derived by matching cosmetic ingredients in the COSMOS Cosmetics Inventory with publicly available oral repeated dose toxicity data. The identification of NOELs includes a full quality control procedure. This dataset of reliable No Observed Effect Level (NOEL) values extends that originally provided in the Munro TTC dataset. For example, the COSMOS database includes many classes of compounds that are not present in the Munro dataset. This will provide greater relevance to the determination of TTC for materials used in cosmetics.
CPCat: Chemical and Product Categories
CPCat (Chemical and Product Categories) is a database containing information mapping >43,000 chemicals to a set of terms categorizing their usage or function. The EPA has compiled a comprehensive list of chemicals with associated categories of chemical and product use by compiling publicly available sources. Sources include, but are not limited to: the Substances in Preparation in Nordic Countries (SPIN) database, information provided by companies, trade associations, and regulatory agencies such as the U.S. Environmental Protection Agency (EPA) and Food and Drug Administration (FDA), the DrugBank database of pharmaceutical products, and information mined from the Aggregated Computational Toxicology Resource (ACToR) database developed by the U.S. EPA. Unique use category taxonomies from each source are mapped onto a single common set of ~800 terms.
DATALOG is a bibliographic file that contains 18 types of environmental fate data, including information about physical properties, environmental degradation, transport processes and monitoring. The file contains over 300,000 records on over 16,000 chemicals.
Department of Energy (DOE) – Oak Ridge National Laboratory Toxicity Profiles
The ~75 toxicity profiles in this database were developed by Oak Ridge National Laboratory staff using information taken from the United States Environmental Protection Agency’s Integrated Risk Information System (IRIS) and Health Effects Assessment Summary Tables (HEAST), and other regulatory sources.
The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The database contains 11,652 drug entries including 2,602 FDA-approved small molecule drugs, 1,075 FDA-approved biotech (protein/peptide) drugs, 128 nutraceuticals and 5,485 experimental drugs. Additionally, 5,126 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data.
Produced by the Translational Informatics Division at the University of New Mexico School of Medicine, Department of Internal Medicine, DrugCentral provides information on active ingredients chemical entities, pharmaceutical products, drug mode of action, indications, pharmacological action. They monitor FDA, EMA, and PMDA for new drug approvals on regular basis to ensure currency of the resource. Limited information on discontinued and drugs approved outside the United States is also available.
EAWAG Biocatalysis/Biodegradation Database
The EAWAG Biocatalysis/Biodegradation Database contains information on microbial biocatalytic reactions and biodegradation pathways for primarily xenobiotic, chemical compounds. The goal of the EAWAG-BBD is to provide information on microbial enzyme-catalyzed reactions that are important for biotechnology. The reactions covered are studied for basic understanding of nature, biocatalysis leading to specialty chemical manufacture, and biodegradation of environmental pollutants. Individual reactions and metabolic pathways are presented with information on the starting and intermediate chemical compounds, the organisms that transform the compounds, the enzymes, and the genes.
Created and maintained by the U.S. EPA, Office of Research and Development (ORD), and the National Health and Environmental Effects Research Laboratory’s (NHEERL’s) Mid-Continent Ecology Division, the ECOTOX (ECOTOXicology) database provides single chemical toxicity information for aquatic and terrestrial life. ECOTOX is a useful tool for examining impacts of chemicals on the environment. Peer-reviewed literature is the primary source of information encoded in the database. Pertinent information on the species, chemical, test methods, and results presented by the author(s) are abstracted and entered into the database.
ENVIROFATE – The Environmental Fate Data Base provides access to available fate data, identifies gaps in information, and provides data sources for degradability of chemicals.
Environment Agency (UK) – Toxicity Reviews
A series of reports has been produced on behalf of the Environment Agency to support the work of the Expert Panel on Air Quality Standards (EPAQS). Each report reviews the sources of release to the atmosphere, a summary of monitoring methods used in the UK, UK ambient concentrations, and the literature on human toxicology and health effects.
Environmental Protection Agency (EPA) – Ambient Water Quality Guidelines
Section 304(a)(1) of the Clean Water Act requires the EPA to develop criteria for water quality that accurately reflects the latest scientific knowledge. These criteria are based solely on data and scientific judgments on pollutant concentrations and environmental or human health effects. Section 304(a) also provides guidance to states and tribes in adopting water quality standards. Criteria are developed for the protection of aquatic life as well as for human health.
Environmental Protection Agency (EPA) – Aggregated Computational Toxicology Online Resource (ACToR)
ACToR aggregates data from thousands of public sources on over 500,000 chemicals. It is searchable by chemical name and other identifiers. ACToR is also the data and web applications warehouse for EPA’s computational toxicology information which includes high-throughput screening, chemical exposure, sustainable chemistry (chemical structures and physicochemical properties) and virtual tissues data.
Environmental Protection Agency (EPA) – Chemical Assessment and Management Program (ChAMP) – Hazard Characterizations
Hazard characterizations are prepared from EPA’s scientific review of the screening-level hazard data set contained within each HPV Challenge Program submission. Agency reviews are performed according to established HPV Challenge Program guidelines and EPA risk assessment guidance. Hazard characterizations are based on data that was provided by sponsors through the HPV Challenge Program, which primarily consists of a specific set of “SIDS” (Screening Information Data Set) endpoints that provide basic information on the physical/chemical properties, environmental fate characteristics, and health and environmental effects of chemicals.
Environmental Protection Agency (EPA) – Chemical Assessment and Management Program (ChAMP) – Risk-Based Prioritizations
Risk-based prioritizations (RBPs) are developed for chemicals that were part of the HPV Challenge Program or the OECD HPV Program, and for chemicals reported as MPV on the 2006 IUR but for which a robust hazard data set (i.e. SIDS) and use and exposure information is available. In other words, an RBP will be developed for all chemicals reported as MPV or HPV on the 2006 IUR if hazard and use/exposure information equivalent to that collected under the HPV Challenge and IUR, respectively, are available.
RBPs for individual chemicals or chemical categories include a qualitative prioritization decision and a qualitative screening-level risk characterization on which the prioritization decision is based. The screening-level risk characterization is developed based on screening-level hazard and exposure characterizations prepared by EPA using data submitted by chemical sponsors under the HPV Challenge Program (or the OECD HPV Program), information submitted under the 2006 Inventory Update Reporting (IUR), and information readily available from publicly accessible databases.
RBPs summarize, qualitatively (high, medium, low), the potential risks of a chemical or chemical category; identify additional information relevant to the Agency’s assignment of a high, medium, or low priority for further attention; and present potential future actions.
Environmental Protection Agency (EPA) – Chemical Assessment and Management Program (ChAMP) – Submissions
These documents are related to the EPA’s HPV Challenge Program and are published “as is.” The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. The U.S. HPV chemicals were identified through information collected under the Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR). Organic chemicals that are manufactured in, or imported into, the United States in amounts equal to or exceeding 10,000 pounds per year are subject to reporting under the TSCA IUR. Reporting is required every four years.
Environmental Protection Agency (EPA) – Chemistry Dashboard
The Chemistry Dashboard is a public resource for computational toxicology research efforts and supports improved predictive toxicology. It provides access to data associated with over 750,000 chemicals. A distinguishing feature of the Chemistry Dashboard is the mapping of curated physicochemical property data associated with chemical substances to their corresponding chemical structures. Millions of predicted physchem properties developed using machine-learning approaches modeling highly curated datasets are also mapped to chemicals within the dashboard.
Environmental Protection Agency (EPA) – Ecological Soil Screening Levels (Eco-SSL)
The Eco-SSLs are concentrations of contaminants in soil that are protective of ecological receptors that commonly come into contact with soil or ingest biota that live in or on soil. EPA derived the Eco-SSLs to conserve resources by limiting the need for EPA and other risk assessors to perform repetitious toxicity data literature searches and data evaluations for the same contaminants at every site. These values can be used to identify those contaminants of potential concern in soils requiring further evaluation in a baseline ecological risk assessment.
Environmental Protection Agency (EPA) – Endocrine Disruptor Screening Program Tier 1 Screening Determinations and Associated Data Evaluation Records
The Endocrine Disruptor Screening Program (EDSP) uses a two-tiered approach to screen pesticides, chemicals, and environmental contaminants for their potential effect on estrogen, androgen and thyroid hormone systems. The EDSP is mandated to use validated methods for the screening and testing chemicals to identify potential endocrine disruptors, determine adverse effects, dose-response, assess risk and ultimately manage risk under current laws. These methods or assays allow EPA to identify and characterize the endocrine activity (specifically, estrogen, androgen and thyroid) of pesticides, commercial chemicals, and environmental contaminants.
Environmental Protection Agency (EPA) – Environmental Chemistry Methods (ECM)
Environmental chemistry methods for soil and water are used to determine the fate of pesticides in the environment. The methods identify and quantify the pesticide residue of interest, determining the total concentration of pesticides, including the extractable parent compound and significant metabolites and degradates (break-down products). Reliable analytical methods are necessary for studies of exposure, environmental fate, and ecological effects. Although the Agency reviews all analytical methods submitted in support of pesticide registration, only about 25% of the currently available environmental chemistry methods have been evaluated in EPA’s laboratory. While most of the methods perform satisfactorily, some have deficiencies, particularly some of the older methods. EPA makes no claim of validity by posting these methods, but recognizes that the methods may be of some utility to state, tribal, and local authorities. Questions about any of these methods should be discussed with EPA’s laboratory staff.
Environmental Protection Agency (EPA) – Fathead Minnow Database
Mid-Continent Ecology Division – MED tested a series of industrial organic compounds using the fathead minnow to develop an expert system to predict the mode of toxic action from chemical structure. The results were also used to develop quantitative structure-activity relationships (QSARs) based on the acute mode of action.
Environmental Protection Agency (EPA) – Health Advisories
The Health Advisory Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical methodology and treatment technology that would be useful in dealing with the contamination of drinking water. Health Advisories (HAs) describe non-regulatory concentrations of drinking water contaminants at which adverse health effects would not be anticipated to occur over specific exposure durations. HAs contain a margin of safety to protect sensitive members of the population and are subject to change as new information becomes available.
Environmental Protection Agency (EPA) – Health Effects Assessments
Published by various programs within the EPA, these reports summarize and evaluate information relevant to assessments of adverse health effects associated with exposure to specific chemicals or compounds. The EPA uses these documents for decision making for the various regulatory programs.
Environmental Protection Agency (EPA) – iCSS ToxCast Dashboard
The iCSS ToxCast Dashboard contains chemical screening data from the Toxicity Forecaster (ToxCast) project and the Toxicity Testing in the 21st century (Tox21) collaboration. The iCSS ToxCast Dashboard integrates data from various sources including:
- ToxCast and Tox21 – High-throughput chemical screening data
- ExpoCast – Chemical exposure data and prediction models
- DSSTox – High quality chemical structures and annotations
- PhysChemDB – Physical Chemical Properties Database
- CPCat – Chemicals listed by associated categories of chemical and product use
Environmental Protection Agency (EPA) – Pesticide Fact Sheets
Published by the EPA, these fact sheets contain information about pesticide chemicals, such as their physical properties, use information, scientific findings and any pertinent regulatory activity.
Environmental Protection Agency (EPA) – Provisional Peer-Reviewed Toxicity Value (PPRTV) Derivation Support Documents
This collection of assessments was developed for the U.S. Environmental Protection Agency (EPA)/Office of Superfund Remediation and Technology Innovation (OSRTI or Superfund). The toxicity values presented were developed in accordance with current Agency guidance on deriving human health toxicity values for EPA’s Superfund Program and were externally peer reviewed. This collection will be periodically updated with current values; therefore, users should ensure that the values are current at the time of use.
Environmental Protection Agency (EPA) – RED Fact Sheets
Published by the EPA, these fact sheets contain summary information about pesticide chemicals and their Registration Status.
Environmental Protection Agency (EPA) – REDs (Re-registration Eligibility Decisions)
When the EPA completes the review and risk management decision for a pesticide that is subject to reregistration (that is, one initially registered before November 1984), the Agency generally issues a Reregistration Eligibility Decision or RED document. The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.
Environmental Protection Agency (EPA) – REDs IREDs (Interim Re-registration Eligibility Decisions)
EPA issues an IRED for a pesticide that is undergoing reregistration, requires a reregistration eligibility decision, and also needs a cumulative assessment as a result of FQPA because it is part of a group of pesticides that share a common mechanism of toxicity. The IRED, issued after EPA completes the individual pesticide’s aggregate risk assessment, may initiate risk reduction measures — for example, reducing risks to workers or eliminating uses that the registrant no longer wishes to maintain — to gain the benefits of these changes before the final RED can be issued, following the Agency’s consideration of cumulative risks.
Environmental Protection Agency (EPA) – Section 4 Chemical Testing
This collection contains the published results of chemical testing under Section 4 of TSCA, which gives EPA the authority to require chemical manufacturers and processors to test existing chemicals. Under Section 4, EPA can by rule require testing after finding that (1) a chemical may present an unreasonable risk of injury to human health or the environment, and/or the chemical is produced in substantial quantities that could result in significant or substantial human or environmental exposure, (2) the available data to evaluate the chemical are inadequate, and (3) testing is needed to develop the needed data.
Environmental Protection Agency (EPA) – SW-846 Methods
The EPA publication SW-846, entitled Test Methods for Evaluating Solid Waste, Physical/Chemical Methods, is the Office of Solid Waste’s official compendium of analytical and sampling methods that have been evaluated and approved for use in complying with the RCRA regulations.
Environmental Protection Agency (EPA) – Substance Registry Services (SRS)
Substance Registry Services (SRS) is the Environmental Protection Agency’s (EPA) central system for information about substances that are tracked or regulated by EPA or other sources. It is the authoritative resource for basic information about chemicals, biological organisms, and other substances of interest to EPA and its state and tribal partners.
Environmental Protection Agency (EPA) – Superfund Chemical Data Matrix (SCDM)
SCDM is a source for factor values and screening concentration benchmarks that can be applied when evaluating potential National Priorities List (NPL) sites using the Hazard Ranking System (HRS). Factor values are part of the HRS equation for determining the relative threat posed by a hazardous waste site and reflect hazardous substance characteristics, such as toxicity and persistence in the environment, mobility and the potential for bioaccumulation. Screening concentration benchmarks are environment- or health-based concentration limits, including some developed by or used in other EPA regulatory programs. SCDM contains HRS factor values and screening concentration benchmarks for hazardous substances that are frequently found at sites evaluated using the HRS, as well as physical, chemical and radiological data used to calculate those values.
Environmental Protection Agency (EPA) – Toxicological Reviews
This database contains peer-reviewed Toxicological Reviews published by the EPA in support of their various programs.
Environmental Protection Agency (EPA) – TREDs (Reports on FQPA Tolerance Reassessment Progress and [Interim] Risk Management Decisions)
A TRED may be issued as a document if no changes in the tolerances for a pesticide are required as a result of EPA’s review. If tolerance revisions are required, then the TRED may be issued as a Federal Register Notice. EPA issues a TRED for a pesticide that requires tolerance reassessment decisions, but does not require a reregistration eligibility decision at present because:
- the pesticide was initially registered after November 1, 1984, and by law is not included within the scope of the reregistration program;
- EPA completed a RED for the pesticide before FQPA was enacted on August 3, 1996; or
- the pesticide is not registered for use in the U.S., but tolerances are established that allow crops treated with the pesticide to be imported from other countries.
Like IREDs, some TREDs will not become final until EPA considers the cumulative risks of all the pesticides in the cumulative group.
Environmental Protection Agency (EPA) – TSCA Test Submissions
The Toxic Substances Control Act of 1976 included several provisions under which the EPA required companies involved in the manufacture, distribution, processing, use, or disposal of chemical substances to submit health and safety studies. This collection contains ~4,000 original submissions in PDF form. These reports, unavailable elsewhere, are frequently internal corporate documents which can contain valuable and hard to find information. The reports, ranging from a few pages to thousands of pages, may be summary in nature, or they may include substantial volumes of data.
Environmental Protection Agency (EPA) – TSCA Workplan Chemical Risk Assessments
As part of the EPA’s continuing comprehensive approach to enhance the Agency’s existing chemicals management program, the EPA identified a work plan of 83 chemicals for further assessment under the Toxic Substances Control Act (TSCA). EPA intends to use the TSCA Work Plan Chemical assessments to help focus and direct the Existing Chemicals Program activities over the next several years. These risk assessments will focus on the potential hazards of the chemical and concerns related to particular uses.
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) – Joint Assessment of Commodity Chemicals Reports (JACC)
JACC Reports (Joint Assessment of Commodity Chemicals) are comprehensive reviews of toxicological and ecotoxicological data on individual chemical substances.
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) – Special Reports
ECETOC Special Reports are compilations of data targeted to specific regulatory issues/demands.
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) – Technical Documents
ECETOC Technical Documents are scientific briefing papers addressing emerging issues.
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) – Technical Reports
ECETOC Technical Reports address specific applications of the science in evaluating the hazards and risks of chemicals to human health and the environment.
European Chemicals Agency (ECHA) – Annex XV Dossiers
Member States Competent Authorities or the European Chemicals Agency (ECHA), on a request by the Commission, may prepare Annex XV dossiers for the identification of substances of very high concern (SVHC). Substances of very high concern are defined in Article 57 of Regulation (EC) No 1907/2006 (“the REACH Regulation”) and include substances which are Carcinogenic, Mutagenic or toxic to Reproduction (CMR), Persistent, Bioaccumulative and Toxic (PBT) or very Persistent and very Bioaccumulative (vPvB), and/or Identified, on a case-by-case basis, from scientific evidence as causing probable serious effects to human health or the environment of an equivalent level of concern as those above (e.g. endocrine disrupters).
European Chemicals Agency (ECHA) – Annex XV Transitional Reports
Annex XV transitional reports of existing substance risk assessments and risk reduction strategies developed under Regulation (EEC) No 793/93, where the work was not finalised by 1 June 2008.
European Chemicals Agency (ECHA) – Biocidal Active Substance Fact Sheets
This collection contains nformation on active substances for which an application for approval for a specific biocidal product-type has been submitted under the Biocidal Products Directive (Directive 98/8/EC) or the Biocidal Products Regulation (Regulation (EU) No 528/2012).
European Chemicals Agency (ECHA) – PACT – RMOA Hazard Assessment Activities
The Public Activities Coordination Tool (PACT) collection includes the completed risk management option analysis (RMOA) or an informal hazard assessment for PBT/vPvB (persistent, bioaccumulative and toxic/very persistent and very bioaccumulative) properties or endocrine disruptor properties since February 2013.
European Chemicals Agency (ECHA) – SVHCs in Consumer Articles
Under the REACH regulations, producers and importers are required to notify ECHA when substances listed on the Candidate List are present in their consumer articles. The reports in this collection are the submissions provided by affected Companies.
European Commission (EC) – EU - Pesticides Database
The EU - Pesticides Database contains MRLs for active substances used in the European Union.
European Commission (EC) – Scientific Committee Reports
Several Scientific Committees provide the Commission with the sound scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The reports contained in this collection include those published by former and current committees tasked with evaluating new or emerging problems which may pose actual or potential threats. This collection includes the following reports:
- Opinions of the Scientific Committee on Consumer Products
- Opinions of the Scientific Committee on Consumers Safety
- Opinions of the Scientific Committee on Cosmetic Products and Non-food products intended for Consumers
- Opinions of the Scientific Committee on Cosmetology
- Opinions of the Scientific Committee on Health and Environmental Risks
- Opinions of the Scientific Committee on Emerging and Newly-Identified Health Risks
- Opinions of the Scientific Committee on Food
- Opinions of the Scientific Committee on Medicinal Products and Medical Devices
- Opinions of the Scientific Committee on Plants
- Opinions of the Scientific Committee for Toxicity, Ecotoxicity and the Environment
- Recommendations of the Scientific Committee on Occupational Exposure Limits
- Reports of the Scientific Committe for Food
European Food Safety Authority (EFSA) – PRAPeR – Pesticide Risk Assessment Peer Review
EFSA is responsible for the EU peer review of active substances used in plant protection products. This task is carried out by EFSA’s Pesticide Risk Assessment Peer Review (PRAPeR) in line with procedures and deadlines set out in the European legislation. The substances covered by the review programme are often referred to as “existing substances” since they were on the market at the time the legislation entered into force So-called “new substances” that have been placed on the market since 1993 are also assessed following the same procedures. The evaluation of both existing and new active substances is done through a tiered approach. Each substance has an initial draft risk assessment report (DAR) produced by a designated Member State, this is followed by a peer review by all Member States, this then leads to a legislative decision to include the substance in the Community’s positive list (Annex I of Directive 91/414/EEC).
European Food Safety Authority (EFSA) – Scientific Documents
A Report can be: (i) a background document annexed to an Opinion of Panel or Scientific Committee, or (ii) a stand-alone document. It pertains to a (literature) review, statistical data analysis, compilation of scientific evidence, such as a compilation/collation/interpretation of survey or monitoring results or a data collection report (iii) a report on the outcome of an EFSA public consultation.
European Food Safety Authority (EFSA) – Statements
EFSA may issue a statement of the Scientific Committee or Scientific Panel which is a scientific output in the form of a concise document adopted by the Scientific Committee or one or more of the Scientific Panels. It may deal with a multitude of subjects within the remit of EFSA and addresses a risk assessment or an evaluation of a risk without providing a full risk assessment. It may be of a provisional or preliminary nature.
European Medicines Agency
The European Medicines Agency (EMA) is responsible for the scientific evaluation, supervision and safety monitoring of medicines in the EU. The Agency evaluates medicines along their lifecycle from early stages of development, through marketing authorisation to safety monitoring once they are on the market and produces a series of publications documenting their activities. This includes public versions of scientific assessment reports and summaries written for professionals and lay people. This collections contains the following:
- Herbal Monographs
- Medicinal Products for Human Use
- Medicinal Products for eterinary Use
European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Genotoxicity & Carcinogenicity Consolidated Database of Ames Positive Chemicals
The EURL ECVAM Genotoxicity & Carcinogenicity Consolidated database compiles available genotoxicity and carcinogenicity data for Ames positive chemicals originating from different sources. This database represents a powerful resource for data analysis that can be used to guide a thorough evaluation of genotoxicity and carcinogenicity. The database is intended, in a first instance, as a resource for evaluating the predictivity of the Ames test for in vivo genotoxicity and carcinogenicity when considered alone or in association with in vitro mammalian cell assays (gene mutation and clastogenicity/aneugenicity) and for a better characterisation of those cases where the Ames test leads to irrelevant (‘false positive’) results. The database may also serve as a platform for detailed structural characterization of specific groups of compounds with or without carcinogenic or genotoxic activity.
FERN Ethnomedicinal Plants Database
The FERN Ethnomedicinal Plants Database contains factual knowledge related to fern ethnomedicinal species. The database includes information on over 100 species and is useful for drug discovery, pharmacology, and botanical researchers.
Flavor and Extract Manufacturers Association (FEMA) – GRAS Flavoring Substances
The primary objective of the FEMA GRAS™ program has been to evaluate whether materials nominated by the flavor industry can be considered “generally recognized as safe” (GRAS) for their intended use as flavor ingredients. This collection includes the results of the Expert Panel’s assessments back to inception.
Flavor and Extract Manufacturers Association (FEMA) – Safety Assessments
In 1993, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a comprehensive program to re-evaluate the safety of more than 1,700 GRAS flavoring substances under conditions of intended use. This collection contains the series of safety evaluations performed by the Expert Panel since inception of the project covering nearly 600 substances.
Flavornet is a compilation of aroma compounds found in human odor space. It lists only those odorants that have been found in a human odor space at supra-threshold levels i.e. at levels likely to stimulate ORNs. A link to a summary page containing chemical properties, sensory descriptors, bibliographies and pdb (protein data bank) files of MM2 minimized structures is provided for each ligand. To be included in Flavornet, an odorant must have been detected in a natural product or real environment by some form of quantitative GCO method (e.g. dilution analysis (Aroma Extraction Dilution Analysis or CharmAnalysis™)) perceived intensity analysis (e.g. Osme) or detection frequency analysis (e.g. SNIFF).
Food and Drug Administration (FDA) – GRAS Notices and Agency Response Letters
In 1997 the FDA issued a proposed rule that would establish a notification procedure whereby any person may notify FDA of a determination by that person that a particular use of a substance is Generally Recognized As Safe (GRAS). Although the proposed notification procedure is not yet final, the FDA started accepting GRAS Notices in 1998. As described in the GRAS proposal, the agency is evaluating whether each submitted notice provides a sufficient basis for a GRAS determination and whether information in the notice or otherwise available to FDA raises issues that lead the agency to question whether use of the substance is GRAS. Following this evaluation, FDA responds to the notifier by letter.
In general, FDA’s response has been in one of three categories:
- The agency does not question the basis for the notifier’s GRAS determination;
- The agency concludes that the notice does not provide a sufficient basis for a GRAS determination (e.g., because the notice does not include appropriate data and information or because the available data and information raise questions about the safety of the notified substance); or
- The response letter states that the agency has, at the notifier’s request, ceased to evaluate the GRAS notice.
The agency has removed non-disclosable information from these submissions. All copyrighted information has also been removed and the bibliographic information listed in a reference table at the end of the submission.
Food and Drug Administration (FDA) – Microbial Mutagenesis Testing Reports
In the late ’70s the FDA commissioned SRI International to study a number of substances for their microbial mutagenicity. This collection contains the reports from those studies.
Food and Drug Administration (FDA) – Mutagenicity Evaluations
In the late ’70s the FDA commissioned a number of studies to evaluate certain test compound for genetic activity in microbial assays. This collection contains the reports from those studies.
Food and Drug Administration (FDA) – Priority-based Assessment of Food Additives (PAFA)
The Priority based Assessment of Food Additive (PAFA) database is a database that serves as Center for Food Safety and Applied Nutrition’s (CFSAN) institutional memory for the toxicological effects of food ingredients known to be used in the United States. Currently, PAFA contains oral toxicology information on over 2,100 of approximately 3,300 direct food ingredients used in food in the U.S. PAFA also contains minimal information on over 3,200 indirect additives including the names, CAS number and regulatory information of the indirect additives in the Code of Federal Regulations. The EAFUS list and the Indirect Additive list on the CFSAN Internet consist of selected fields of information generated from PAFA.
Food and Drug Administration (FDA) – Scientific Literature Reviews on Generally Recognized as Safe (GRAS) Food Ingredients
The Scientific Literature Reviews summarize the available scientific literature from 1920 to 1973 related to the safety of food ingredient Generally Recognized as Safe (GRAS). Chemical information, biological data, and biochemical aspects of the ingredients are captured in each report.
Food and Drug Administration (FDA) – Select Committee on GRAS Substances (SCOGS) Reports
This database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.
Food and Drug Administration (FDA) – Summaries of Medical and Clinical Pharmacology Reviews
The FDA's Center for Drug Evaluation and Research conducts Medical and Clinical Pharmacology Reviews of drugs undergoing the approval process. These documents include Medical, Clinical, or Pharmacolgical Reviews and cover the FDA's Recommendation on Regulatory Action.
Food and Drug Administration (FDA) – Teratologic Evaluations
the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT), the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM) and the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC) publish an annual report that provide a brief background to the Committees' decisions during that year.
Food Standards Agency (UK) - Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment
In the early 1970s, the FDA funded studies on the teratologic effects of nearly 100 food additives. This collection contains the reports of all evaluated substances.
French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
The National Agency for Food Safety, Environment and Labor (ANSES) is a French government agency whose main mission is the evaluation of health risks in the fields of food, plants, and the environment. ANSES fully addresses all types of risks (chemical, biological, physical, etc.) including through exposure at work, at home, or via diet. This collection includes English-language versions of their Opinions, Reports, and Publications.
Gastrointestinal Absorption Database (GIABS)
GIABS contains bibliographic citations to studies of absorption, distribution, metabolism, or excretion of chemical substances by human or animal test subjects. Each record deals with a specific experiment on a specific chemical as abstracted from a specific article. The collection contains more than 12,000 references concerning 3,779 different chemical substances.
Created by the U.S. Environmental Protection Agency (EPA), GENE-TOX contains genetic toxicology (mutagenicity) test data, resulting from expert peer review of the open scientific literature, on over 3,000 chemicals. The GENE-TOX program was established to select assay systems for evaluation, review data in the scientific literature, and recommend proper testing protocols and evaluation procedures for these systems.
GESTIS Analytical Methods
This database contains validated lists of methods from various EU member states, the USA and Canada described as suitable for the analysis of chemical agents at workplaces.
GESTIS Derived No-Effect Levels (DNELs)
The DGUV GESTIS DNEL list currently contains Derived No-Effect Levels (DNELs) for workers (local and/or systemic effects during long-term inhalation exposure) for roughly 4,800 substances. If different DNELs are published for a single substance, they are presented side-by-side. Carcinogens are specially marked. If there is also a workplace limit value that is binding in Germany, this is indicated.
GESTIS Substance Database
The GESTIS Substance Database contains information for the safe handling of hazardous substances work. The database contains important physical and chemical properties as well as special regulations (e.g. GHS classification and labeling according to CLP regulation (pictograms, H phrases, P phrases)). At this point the database covers about 9,400 substances.
GHS – Japan
The GHS-Japan database comprises GHS classification results by the Japanese government since 2006. This database includes GHS classification guidance by the Japanese government and classification results (classification, symbol, signal word, hazard statement and precautionary statement) in accordance with the guidance. These classifications are an advisory classification and intended to be used as reference for preparing GHS labelling and SDS by enterprises.
Globinmed (Global Information Hub On Integrated Medicine) Databases
Globinmed is a unique interactive resource with validated, up-to-date and comprehensive content on Integrated Medicine. It contains comprehensive content on herbs, plants, essential oils, and dietary supplements.
Globinmed comprises these databases:
- Ayurveda Herbs
- Dietary Supplements
- Essential Oil
- Herbal Monographs
- Medicinal Herbs & Plants Database
- Medicinal Herbs & Plants (Consumer)
- Native American Herbs
- Poisonous Plants Database
- Safety of Herbal
- South Central America Herbs
- South Africa Herbs
- Traditional Chinese Medicine Herbs (Professional)
- Western Herbs
Government of Canada – Chemicals Management Plan – Challenge Substance Submissions
Since the launch of the Chemicals Management Plan (CMP) in 2006, the Government of Canada has worked closely with health and environmental groups, consumer groups and industry to reduce risks to Canadians and the environment by setting clear priorities for the assessment and management of hundreds of chemicals. The documents in this collection include Screening Assessments, Risk Management Approaches, and Public Comments on the high-priority chemical substances included in the CMP “Challenge”.
Government of Canada – Chemicals Management Plan – Priority Substances List Assessments
Since 1994, under the Canadian Environmental Protection Act of 1988 (CEPA 1988) and the Canadian Environmental Protection Act, 1999 (CEPA 1999), Environment Canada and Health Canada have conducted assessments of “existing substances” that were introduced prior to 1994. Many of these substances had not previously been examined for their potential risks by environmental and health scientists in government. These assessments, a scientific evaluation of a chemical substance to determine the potential harm or danger it can cause to human health and/or the environment and the ways in which it can happen, allow the federal government to identify the control measures needed to avoid or prevent the potential harm.
GSBL (Joint Substance Data Pool of the German Federal Government and the German Federal States)
The Joint Substance Data Pool of the German Federal Government and Federal States (GSBL) is a continuously maintained, uniform collection of validated information on chemical substances. The mission of the cooperation is to provide public authorities and the general public with reliable, topical chemicals information in support of all activities to prevent and avert danger and to protect humans and the environment.
GSBL represents a wide range of features of chemical substances. Records contain information on physical and chemical properties, on ecotoxicological and toxicological parameters and on environmental fate. They provide descriptions of environmental hazards, health dangers, fire and other technical hazards and give information on relevant chemicals-related legislation.
Published by Jay Brown, M.D. MPH, Haz-Map® is an occupational health database containing profiles on thousands of chemicals covering common uses, adverse effects, and other information needed for exposure assessment. Jobs and hazardous job tasks are linked to occupational diseases and their symptoms while chemicals are linked to associated industrial processes and non-occupational activities. Each chemical is also linked to any of the 225 occupational diseases in the database in which a causal relationship has been established. These documents are written using hundreds of resources including highly-regarded peer-reviewed textbooks, journal articles, and electronic databases.
Hazardous Chemical Information System (HCIS)
Produced by Safe Work Australia, HCIS is a database of chemical classifications and workplace exposure standards. It allows you to find information on chemicals that have been classified in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or which have an Australian Workplace Exposure Standard.
Hazardous Substances Data Bank (HSDB®)
Produced by The National Library of Medicine, HSDB is a toxicology data file that focuses on the toxicology of over 4,500 potentially hazardous chemicals. It is enhanced with information on human exposure, industrial hygiene, emergency-handling procedures, environmental fate, regulatory requirements, and related areas. All data are referenced and derived from a core set of books, government documents, technical reports and selected primary journal literature. HSDB is peer-reviewed by the Scientific Review Panel (SRP), a committee of experts in the major subject areas within the data bank’s scope.
Herbwisdom is a website that assembles information about herbs and health food from various sources and presents it in a friendly and understandable way. The site currently provides articles on over 200 herbs, written from an impartial viewpoint.
HERA Risk Assessments
Produced by the HERA (Human and Environmental Risk Assessment) initiative, this collection is a series of Human and Environmental Risk Assessments on ingredients of household cleaning products used in Europe.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Published by the International Agency for Research on Cancer (IARC), these Monographs identify environmental factors that can increase the risk of human cancer. These include chemicals, complex mixtures, occupational exposures, physical and biological agents, and lifestyle factors. National health agencies use this information as scientific support for their actions to prevent exposure to potential carcinogens. Interdisciplinary working groups of expert scientists review the published studies and evaluate the weight of the evidence that an agent can increase the risk of cancer. The principles, procedures, and scientific criteria that guide the evaluations are described in the Preamble to the IARC Monographs. Since 1971, more than 1,000 agents have been evaluated, of which approximately 400 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.
Information System for Hazardous Organics in Water (ISHOW)
ISHOW covers six types of physical property data: melting point, boiling point, vapor pressure, water solubility, log partition coefficient (Log P) and dissociation constants. Bibliographic references are also included. The collection contains approximately 16,000 records covering 5,400 chemicals.
Integrated Risk Information System (IRIS)
IRIS is a database of human health effects that may result from chronic exposure to various chemical substances found in the environment. IRIS currently provides information on the chronic health effects–both cancer and non-cancer–associated with more than 500 chemical substances. The database includes chemical-specific summaries of qualitative and quantitative health information in support of the first two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. Combined with specific situational exposure assessment information, the information in IRIS is an important source in evaluating potential public health risks from environmental contaminants.
Integrated Risk Information System (IRIS) – Literature Searches
The EPA conducts literature searches for substances subject to ongoing or future assessments. Based on the results of the literature searches and as EPA resources allow, assessments will be started for those chemicals with data that may support development of one or more toxicity values. The documents found in this collection are the results of the literature searches.
IPCS – Concise International Chemical Assessment Documents (CICADS)
Published by the International Programme on Chemical Safety (IPCS) – a cooperative program of the World Health Organization (WHO), the International Labor Organization (ILO), and the United Nations Environment Programme (UNEP), CICADs are concise documents that provide summaries of the relevant scientific information concerning the potential effects of chemicals upon human health and/or the environment. The primary objective of CICADs is characterization of hazard and dose-response from exposure to a chemical. CICADs are not a summary of all available data on a particular chemical; rather, they include only that information considered critical for characterization of the risk posed by the chemical. The critical studies are, however, presented in sufficient detail to support the conclusions drawn.
IPCS – Environmental Health Criteria Monographs (EHC)
Published by the International Programme on Chemical Safety (IPCS) – a cooperative program of the World Health Organization (WHO), the International Labor Organization (ILO), and the United Nations Environment Programme (UNEP), EHC Monographs are designed for scientists and administrators responsible for the establishment of safety standards and regulations. are based on a comprehensive search of available original publications, scientific literature and reviews and examine: the physical and chemical properties and analytical methods; sources of environmental and industrial exposure and environmental transport, chemobiokinetics and metabolism including absorption, distribution, transformation and elimination; short- and long-term effects on animals (carcinogenicity, mutagenicity, and teratogenicity); and finally, an evaluation of risks for human health and the effects on the environment.
IPCS – Health and Safety Guides (HSG)
Published by the International Programme on Chemical Safety (IPCS) – a cooperative program of the World Health Organization (WHO), the International Labor Organization (ILO), and the United Nations Environment Programme (UNEP), HSGs provide concise information in non-technical language, for decision-makers on risks from exposure to chemicals, with practical advice on medical and administrative issues.
IPCS – Poison Information Monographs (PIMs)
PIMs, prepared by collaborating poison information centres throughout the world, contain information on substances (chemicals, pharmaceuticals, poisonous plants, and poisonous and venomous animals) commonly involved in cases of poisoning. A PIM is a concise, practical document that summarizes the physico-chemical and toxicological properties of the substance, the medical features of the effects produced by various routes of exposure to the substance, and patient management.
ITER – International Toxicity Estimates for Risk Assessment
Published by TERA (Toxicology Excellence for Risk Assessment), ITER is database of human health risk values and cancer classifications for over 680 chemicals of environmental concern from multiple organizations worldwide. ITER presents risk data in a tabular format for easy comparison, along with a synopsis explaining differences in data and a link to each organization for more information.
Japan Existing Chemical Data Base (JECDB)
Japan has been studying chemical toxicity under the initiative of the National Institute of Health Sciences and has also been performing safety tests of existing chemicals with high production volume (HPV) in cooperation with the U.S., the EC, and other OECD member countries as one of the OECD Chemicals Programme Group members since 1991. This collection contains the results of toxicity studies conducted for individual environmental chemicals include a single dose toxicity test, a 28-day repeat dose toxicity test, a reproductive/development toxicity test and mutagenicity tests. The Abstracts (in English) are written covering all toxicity tests conducted for the chemical in question.
Joint Research Centre (JRC) (formerly European Chemical Bureau) – IUCLID Reports
Substances on the EU Priority Lists must undergo an in-depth risk assessment covering the risks posed by the priority chemical to man (covering workers, consumers and man exposed via the environment) and the environment (covering the terrestrial, aquatic and atmospheric eco-systems and accumulation through the food chain). The comprehensive risk assessment report is subsequently published in the International Uniform Chemical Information Database (IUCLID).
Joint Research Centre (JRC) (formerly European Chemical Bureau) – PBT Summary Fact Sheets
PBT Summary Fact Sheets provide information on Existing Substances which have been subject to evaluation of their PBT properties under the Interim Strategy for REACH and the ESR program.
Joint Research Centre (JRC) (formerly European Chemical Bureau) – Risk Assessment Reports
Substances on EU priority lists must undergo an in-depth risk assessment covering the risks posed by the priority chemical to man (covering workers, consumers and man exposed via the environment) and the environment (covering the terrestrial, aquatic and atmospheric eco-systems and accumulation through the food chain). This risk assessment follows the framework set out in Commission Regulation (EC) 1488/94 and implemented in the detailed Technical Guidance Documents (TGD) on Risk Assessment for New and Existing Substances.
The LactMed® database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. Suggested therapeutic alternatives to those drugs are provided, where appropriate. All data are derived from the scientific literature and fully referenced. A peer review panel reviews the data to assure scientific validity and currency.
L’Institut national de l’environnement industriel et des risques (INERIS) – Seuils de toxicité aiguë – Émissions accidentelles des substances chimiques dangereuses dans l’atmosphère
This is a French-language collection of INERIS reports containing scientific support for the development of acute toxicity thresholds applicable to the risks related to accidental emissions of dangerous chemicals in the atmosphere.
L’Institut national de l’environnement industriel et des risques (INERIS) – Fiche de données toxicologiques et environnementales des substances chimiques
This is a French-language collection of INERIS toxicological and environmental data sheets for chemicals. The data sheets data gathered from sources that include internationally-renowned organizations and peer-reviewed authors. Topics include chemical and physical properties, environmental fate, exposure assessment parameters, ecotoxicological data, and environmental methods of detection and quantitation.
L’Institut national de l’environnement industriel et des risques (INERIS) – Normes de Qualité Environnementale (NQE) et Valeurs Guides Environnementales (VGE)
This is a French-language collection of INERIS reports containing scientific support for the development of Environmental Quality Standards and Environmental Guide Values.
L’Institut national de l’environnement industriel et des risques (INERIS) – Données technico-économiques sur les substances chimiques en France
This is a French-language collection of INERIS techno-economic data sheets for chemicals. The data sheets cover topics such as regulations, production methods, release routes, discharge reduction, and economic factors.
Longwood Herbal Task Force Documents
Founded by faculty and staff from Children's Hospital, the Massachusetts College of Pharmacy and Health Sciences, and the Dana Farber Cancer Institute, the Longwood Herbal Task Force aims to help educate clinicians about the use of herbal remedies and other dietary supplements. It offers an extensive collection of monographs, information summaries, fact sheets, and other content useful to health care providers. Information on a wide range of herbs is provided, including herb-drug and herb-nutrient interactions.
MedFacts Natural Products
The MedFacts Natural Products Professional database is a comprehensive source of information on traditional and/or conventional uses of natural products. A basic overview of each product is provided (including dosages, possible drug interactions, side effects and contraindications) along with safety and/or efficacy ratings from Wolters Kluwer Health.
Medicinal Plant Database for Drug Designing (MPD3)
MPD3 provides phytochemicals, activities, structural, and test target information about medicinal plants with reference to original research papers, PubMed Central Id and PubChem structures. The database contains information about more than 5000 phytochemicals from around 1000 medicinal plants with 80 different activities, more than 900 literature references and 200 plus targets.
MedlinePlus - Drugs, Herbs and Supplements
MedlinePlus is the National Institutes of Health's web site for patients, their families, and friends. It is produced by the National Library of Medicine, the world’s largest medical library. As part of MedlinePlus, Drugs, Herbs and Supplements delivers a wealth of valuable information. This includes data on prescription drugs and over-the-counter medicines, such as side effects, dosage, special precautions, and more. Information on dietary supplements and herbal remedies is also included, such as effectiveness, usual dosage, and drug interactions. The information in Drugs, Herbs, and Supplements is uniformly well-sourced, easy to understand, and geared to a wide variety of audiences.
Memorial Sloan Kettering Cancer Center - About Herbs
The About Herbs database can help identify the value of using common herbs and other dietary supplements. A pharmacist and botanicals expert manages and continually updates the database with assistance from other MSK Integrative Medicine Service experts, providing objective and evidence-based information that can be helpful in judging a product’s:
- traditional and proven uses
- potential benefits
- possible adverse effects
- interactions with other herbs or medicines
National Center for Complementary and Integrative Health (NCCIH) - Herbs at a Glance
Herbs at a Glance, produced by the National Center for Complementary and Integrative Health (NCCIH), is a series of brief fact sheets that provide basic information about specific herbs or botanicals. This includes common names, scientific data, potential side effects and cautions, and resources for more information. Herbs at a Glance records contain background information about the herb, knowledge based on research, safety information, and much more. Images are also included to facilitate identification.
National Institute of Standards and Technology (NIST) – Chemistry WebBook
The NIST Chemistry WebBook provides access to data compiled and distributed by NIST under the Standard Reference Data Program. The database currently consists mostly of organic compounds along with a few small inorganic compounds.
Those who need a quick way to obtain information on environmental contaminants issues are the intended audience. Many types of information other than environmental, regulatory, and toxic concentrations are also in the Encyclopedia, including brief sections at the beginning of each entry which give general overviews on the compound, its hazards, its more dangerous toxic effects (carcinogenic, developmental, reproductive, endocrine, genotoxic), and its environmental fate. Although originally developed for use by staff in the National Park Service and other federal agencies, this product is being made broadly available to anyone who may find it useful, such as: Contaminants specialists, environmental toxicologists, hazardous waste specialists, environmental risk assessors, natural resource damage assessors, contaminants researchers, land managers, spill responders, water quality specialists, and natural resource managers, are all among intended users. Libraries, academia, state governments, local governments, environmental consulting firms, and environmentally-concerned members of the general public are all among non-federal groups who may find this product useful.
National Institute of Environmental Health Sciences (NIEHS) - AIDS Therapeutics Toxicity Reports
The National Institute of Environmental Health Sciences (NIEHS), under the AIDS research program, collaborates with other institutes of the NIH, other government agencies, and pharmaceutical companies to evaluate the reproductive/developmental toxicity, general toxicity, immunotoxicity and neurotoxicity of AIDS therapeutics. These evaluations may include single therapeutic agents or combination therapies when the toxic potential of these agents in animal models is not available or is incomplete. The studies with combination therapies are very important in that they will increase awareness and understanding of interactions between antiretroviral therapies and other drugs/substances that HIV-infected individuals may be using.
National Institute for Occupational Safety and Health (NIOSH) - Criteria Documents
Under the authority of the Occupational Safety and Health [29 USC 1900] and the Mine Safety and Health Act [30 USC 80], NIOSH develops and recommends criteria for preventing disease and hazardous conditions in the workplace. NIOSH recommended exposure limits (RELs) are examples of such criteria. NIOSH also recommends preventive measures (e.g., engineering controls, safe work practices, personal protective equipment, and environmental and medical monitoring) for reducing or eliminating the adverse health effects of these hazards. Criteria documents are developed to provide the basis for the comprehensive occupational safety and health standards. These documents generally contain a critical review of the scientific and technical information available on the prevalence of hazards, the existence of safety and health risks, and the adequacy of methods to identify and control hazards. Recommendations for minimizing safety and health risks include medical monitoring, exposure assessment, worker training, control technology, personal protective equipment, and recordkeeping as well as RELs where appropriate. Criteria documents are developed primarily for the U.S. Department of Labor (OSHA and MSHA); however, they are also distributed to health professionals in academia, industry, organized labor, public interest groups, and other Federal, State, and local government agencies.
National Institute for Occupational Safety and Health (NIOSH) - IDLH Documentation
This publication documents the criteria and information sources that have been used by the National Institute for Occupational Safety and Health (NIOSH) - to determine immediately dangerous to life or health concentrations (IDLHs). IDLHs were originally determined for 387 substances in the mid-1970s as part of the Standards Completion Program (SCP), a joint project by NIOSH and the Occupational Safety and Health Administration (OSHA), for use in assigning respiratory protection equipment.
National Institute for Occupational Safety and Health (NIOSH) - International Chemical Safety Cards (ICSC)
International Chemical Safety Cards summarize essential health and safety information on chemicals for their use at the “shop floor” level by workers and employers in factories, agriculture, construction and other work places. The U.S. National Version is made available by NIOSH and has been edited to reflect U.S. Standards.
National Institute for Occupational Safety and Health (NIOSH) - Manual of Analytical Methods (NMAM®)
NMAM is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. These methods have been developed specifically to have adequate sensitivity to detect the lowest concentrations as regulated by OSHA and recommended by NIOSH, and sufficient range to measure concentrations exceeding safe levels of exposure. The methods have been developed or adapted by NIOSH or its contractors and have been evaluated according to established experimental protocol and evaluation criteria. NMAM also includes chapters on quality assurance, strategies of sampling airborne substances, method development and discussions of some portable direct-reading instrumentation.
National Institute for Occupational Safety and Health (NIOSH) - Occupational Health Guidelines
Summarizes information on permissible exposure limits, chemical and physical properties, and health hazards. It provides recommendations for medical surveillance, respiratory protection, and personal protection and sanitation practices for specific chemicals that have Federal occupational safety and health regulations.
National Institute for Occupational Safety and Health (NIOSH) - Pocket Guide (NPG)
The NPG is intended as a source of general industrial hygiene information on several hundred chemicals/classes for workers, employers, and occupational health professionals. The NPG does not contain an analysis of all pertinent data, rather it presents key information and data in abbreviated or tabular form for chemicals or substance groupings (e.g. cyanides, fluorides, manganese compounds) that are found in the work environment. The information found in the NPG should help users recognize and control occupational chemical hazards.
National Institute for Occupational Safety and Health (NIOSH) - Specific Medical Tests Published in the Literature for OSHA Regulated Substances
The MEDTEST database lists the specific medical tests published in the literature for OSHA regulated substances. Updates of OSHA mandated tests (July 1, 2000) and NIOSH/OSHA recommendations are included.
National Institute of Technology and Evaluation – Chemical Risk Information Platform (NITE-CHRIP)
NITE-CHRIP provides comprehensive information such as Risk Assessments and Laws & Regulations for chemical substances found in commerce in Japan.
National Toxicology Program – Chemical Effects in Biological Systems (CEBS)
Chemical Effects in Biological Systems (CEBS), is a database of toxicology and toxicogenomics study information and data from NTP, National Institute of Environmental Health Sciences (NIEHS), other government agencies, academia, and pharmaceutical companies.
National Toxicology Program – Chemical Repository
Between 1978 and 1991 a contractor assembled health and safety background information for chemicals selected for study by the NTP. These documents were provided to the laboratories to help them develop the individual health and safety plans before conducting any testing. This set of Health & Safety files was made available at a time when there was no other single comprehensive web source, especially for safety information. At this point the NTP does not plan to update these files.
National Toxicology Program – Genetically Modified Model Studies
Over the past few years, the NIEHS/NIH and NTP have been actively evaluating transgenic strains in toxicological testing strategies. Based on completed evaluations, two models, the p53 deficient (p53+/- heterozygous) and Tg.AC (v-Ha-ras transgene), have shown potential usefulness in identifying carcinogens and mechanisms of action. Data from studies with these two models were presented to the NTP Board of Scientific Counselors (BSC) for their review and comment together with plans for future NTP studies with genetically manipulated animal models. This collection includes Draft and Final Reports.
National Toxicology Program – Genetically Modified Model Study Abstracts
These abstracts are taken from the published GMM reports.
National Toxicology Program – Immunotoxicology Study Abstracts
These abstracts are taken from the published IMM reports.
National Toxicology Program – Long-Term Toxicology and Carcinogenesis Study Abstracts
These abstracts are taken from the published long-term toxicology and carcinogenesis study reports.
National Toxicology Program – Long-Term Toxicology and Carcinogenesis Studies
These studies are designed and conducted to characterize and evaluate the toxicologic potential, including carcinogenic activity, of selected chemicals in laboratory animals (usually two species, rats and mice). Chemicals selected for NTP toxicology and carcinogenesis studies are chosen primarily on the bases of human exposure, level of production, and chemical structure. The interpretive conclusions presented in this Technical Report are based only on the results of these NTP studies. Extrapolation of these results to other species and quantitative risk analyses for humans require wider analyses beyond the purview of these studies. Selection per se is not an indicator of a chemical’s carcinogenic potential.
National Toxicology Program – Report on Carcinogens – All Volumes since inception (1-14)
The Report on Carcinogens (RoC), previously called the Annual Report on Carcinogens, is a congressionally mandated, science-based, public health report that identifies agents, substances, mixtures, or exposures (collectively called “substances”) in our environment that may potentially put people in the United States at increased risk for cancer. Published biennially by The National Toxicology Program (NTP) on behalf of the Secretary, Health and Human Services, each edition of the report is cumulative and consists of substances newly reviewed in addition to those listed in previous editions. The 14th RoC, the latest edition, was published on November 3, 2016.
National Toxicology Program – Report on Carcinogens – Background Documents
Background documents are prepared for each nomination under consideration for the ROC. Each is prepared by the NTP with the assistance of a consultant or a panel of consultants who have expertise and/or knowledge for the specific nomination that was relevant to its evaluation of carcinogenicity.
National Toxicology Program – Report on Carcinogens – Candidate Substances
As part of the official “Process for Preparation of the Report on Carcinogens”, the NTP, with Interagency review, publishes a series of documents that lead to the creation of the Final RoC Monograph. This collection includes those documents as they become available.
National Toxicology Program – Developmental and Reproductive Toxicology (DART) Abstracts
The NTP Developmental and Reproductive Toxicology (DART) Study Abstracts collection contains the abstracts as taken from the published DART reports
National Toxicology Program – Developmental and Reproductive Toxicology (DART) Studies
The Developmental and Reproductive Toxicology Studies characterize the developmental and reproductive toxicity potential of chemicals, herbals, and pharmaceuticals nominated to the NTP for assessment. .
National Toxicology Program – Reproductive Assessment by Continuous Breeding (RACB) Studies
As part of its charge to test chemicals of concern for potential toxicity, the NTP evaluates reproductive toxicity using the design Reproductive Assessment by Continuous Breeding (RACB). This two-generation study design was developed by the NTP for use in identifying potential hazards to toxic effects on male and/or female reproduction, to characterize that toxicity, and to define the dose-response relationships for each compound. These studies have been performed by laboratories under contract to the National Institute of Environmental Health Sciences (NIEHS) using Good Laboratory Practices.
National Toxicology Program – Reproductive Assessment by Continuous Breeding (RACB) Study Abstracts
These abstracts are taken from the published RACB reports.
National Toxicology Program – Reviews of Toxicological Literature
The NTP conducts Reviews of Toxicological Literature on chemicals nominated for study. These reports are those made available by the NTP on their website.
National Toxicology Program – Short-Term Developmental and Reproductive Toxicity Abstracts
The NTP Short-term Toxicity Developmental and Reproductive Toxicity Study Abstracts collection contains the abstracts as taken from the published reports (RDGT) of the NTP.
National Toxicology Program – Short-Term Developmental and Reproductive Toxicity Studies
The purpose of the RDGT studies is to assess the general reproductive and developmental toxicities of chemicals identified by the U.S. Environmental Protection Agency as possible drinking-water contaminants using the National Toxicology Program’s Short-Term Reproductive and Developmental Toxicity Screen protocol.
National Toxicology Program – Short-Term Study Abstracts
The NTP Short-term Toxicity Study Abstracts collection contains the abstracts as taken from the published toxicity reports (TOX) of the NTP.
National Toxicology Program – Short-Term Toxicity Studies
This database is a collection of published toxicity reports (TOX) of the NTP. The chemical exposure period for most of these studies was up to 13-weeks. Studies are conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations (21 CFR, Part 58). These NTP toxicology studies have been reviewed by a Technical Reports Review Subcommittee, a standing subcommittee of the NTP Board of Scientific Counselors, which provides peer review of the draft toxicity reports.
National Toxicology Program – Teratology Studies
The NTP effort in developmental toxicity arose in the late 1970s. One of the primary goals is to determine the developmental toxicity of chemicals to which a wide segment of the population is exposed. In this case, that population consists of women of childbearing age, primarily pregnant women. Since it is difficult to assess exposure to potential developmental toxicants and outcome of exposure within this group, well controlled animals studies must provide a basis for human risk assessment. For this purpose, most studies are designed to determine a dose-response relationship in addition to the detection of a potential for developmental toxicity. This program area is developing a wide range of techniques for evaluating potential toxic effects of chemical exposure on the reproductive system of humans and rodent models and the developing embryo of rodent models. Research efforts are directed towards understanding the site and mechanism of action of reproductive and developmental toxicants.
National Toxicology Program – Teratology Study Abstracts
These abstracts are taken from the published Teratology reports.
New Jersey Hazardous Substances Fact Sheets
The New Jersey Hazardous Substances Fact Sheets database provides users with easy to read and summarized fact sheets, containing hazard data and safe working procedures for over 1,000 chemicals. For each hazardous chemical, there is a summary of potential hazards, workplace exposure limits, workplace control measures, human health effects (short- and long-term), medical testing recommendations, spill and emergency response, and other safety information.
Native American Ethnobotany Database
This database describes plants used as drugs, foods, dyes, fibers, and more, by native Peoples of North America. The database, with over 44,000 items, represents uses by 291 Native American groups of 4,029 species from 243 different plant families. About half of them are medicinal.
Nordic Expert Group Criteria Documents
The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals (NEG) consists of scientific experts from the Nordic countries representing different fields of science, such as toxicology, occupational hygiene and occupational medicine. The main task is to produce criteria documents to be used by the regulatory authorities of the Nordic countries as the scientific basis for setting occupational exposure limits (OELs) for chemical substances.
Office of Health Assessment and Translation (OHAT) – (Formerly CERHR) – Expert Panel Reports
The Expert Panel Reports provide a consensus scientific judgment of the potential human reproductive and developmental toxicity of chemical agents or mixtures.
Office of Health Assessment and Translation (OHAT) – (Formerly CERHR) – Monographs
The CERHR follows a formal process for the evaluation of selected chemicals that includes opportunities for public input. The NTP-CERHR monographs are the final products of those evaluations. NTP-CERHR monographs include three parts: (1) The NTP brief, which presents the NTP’s interpretation of the available data and its conclusions on the potential for a chemical to cause adverse developmental and reproductive effects in humans, (2) the expert panel report, and (3) all public comments on the expert panel report. The NTP utilizes information provided in the expert panel report, the public comments, as well as information from studies published since the expert panel meeting in reaching its conclusions about any potential hazard for humans.
The Oil and Hazardous Materials – Technical Assistance Data System (OHM-TADS) is specifically designed to facilitate rapid access to data on 1,402 oil and hazardous substances. OHM-TADS provides vital information to spill response team personnel, especially in emergency situations where readily accessible information on the degree of the hazards involved, appropriate countermeasures, and effective personnel safety precautions is of critical importance. Quantitative data and interpretative comments found in the 126 fields that constitute OHM-TADS can be used as a basis for decision making and initiation of corrective action for both on-scene coordinators and emergency response teams. Additionally, OHM-TADS covers regulatory information, including shipping requirements and water standards, as well as a wide variety of physical, chemical, biological, toxicological, and commercial data of value for enforcement and research activities. Sources of information presented in OHM-TADS include journal articles, symposia papers, government reports, and basic reference texts.
Organisation for Economic Co-operation and Development (OECD) Existing Chemicals Database
The OECD Existing Chemicals Database contains all documents associated with the final published assessment (profiles, assessment reports and dossiers) for chemicals that have been or are being investigated in the OECD Cooperative Chemicals Assessment Programme. The collection also tracks all chemicals through the assessment process. High production volume (HPV) chemicals are tracked from the time that they are identified as an HPV to OECD until a full SIDS assessment has been completed. Other chemicals (such as targeted assessments) are tracked from either the time they are identified to OECD or when they are submitted for discussion at a Cooperative Chemicals Assessment Meeting (CoCAM) through completion. The database contains any annotations on each chemical provided to the Secretariat by member countries.
OSHA Comments on PELs
The database is derived from OSHA comments from the January 19, 1989 Final Rule on Air Contaminants Project extracted from 4FR2332 et. seq. This rule was remanded by the U.S. Circuit Court of Appeals and the limits are not currently in force.
OSHA Occupational Chemical Database
OSHA maintains this chemical database as a convenient reference for the occupational safety and health community. It compiles information from several government agencies and organizations.
OSHA Sampling and Analytical Methods
OSHA technical reference materials for industrial hygienists regarding sampling and analytical methods.
OSPAR Commission Monographs
Produced by the OSPAR Commission, these monographs provide background support and advisory information used to set and implement pollution reduction strategies in the North Sea.
Pharmaceuticals in the Environment, Information for Assessing Risk (PEiAR)
Produced by the National Centers for Coastal Ocean Science (NCCOS), this database is designed to provide available information for assessing risks to aquatic resources from drugs entering waterways from both point and non-point sources. It includes information on prescribed amounts, levels detected in aquatic environments, chemical structure, molecular weight, octanol-water partition coefficients, water solubility, environmental persistence, general toxicity information and specific toxicity levels to five groups of organisms (algae, mollusks, finfish, crustaceans, and select terrestrial animals). Toxicity to terrestrial animals is provided as a general comparison to a large body of available toxicological literature. All of this information was obtained from available scientific literature and is provided to assist identifying locations where risks to aquatic organisms might occur.
Phytochemical and Drug Target Database (PDTDB)
The Phytochemical and Drug Target Database (PDTDB) is a database for plant metabolites, drug targets, and target-ligand complexes. It contains information about phytochemical compounds, plant sources for phytochemical compounds, drug targets, symptoms and causes of diseases, and natural remedies to cure them. Most records covering the plants, phytochemicals, diseases, and drug targets are hyperlinked to the related entries and reference the original resource.
PubChem, released in 2004, provides information on the biological activities of small molecules. The PubChem Compound Database contains validated chemical depiction information that is provided to describe substances found in PubChem Substance. Structures stored within PubChem Compound are pre-clustered and cross-referenced by identity and similarity groups. Additionally, calculated properties and descriptors are available for searching and filtering of chemical structures.
PubChem GHS Classifications
PubChem compiles GHS Classifications for over 4,000 substances from 4 sources and provides them as a single document for users interested in Hazard and Precautionary Statements.
PubChem Laboratory Chemical Safety Summaries
The Laboratory Chemical Safety Summary (LCSS) is based on the format described by the National Research Council in the publication “Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards” (2011). The LCSS in PubChem contains pertinent chemical hazard and safety information. It is available when a GHS Classification (Globally Harmonized System of Classification and Labelling of Chemicals) is present for a given PubChem Compound record.
Public Health England – Chemical Hazards Compendium
Produced by the Public Health England, the Chemical Hazards Compendium covers three areas:
- General information on the chemical
- Toxicological overview of the compound
- Incident management focusing on information needed during chemical incidents, such as physicochemical properties, health effects and decontamination
REPROTOX ® is an information system developed by the Reproductive Toxicology Center (RTC). It contains commentaries on the potentially harmful effects of chemicals and physical agents on human pregnancy, reproduction, and development. The REPROTOX ® system was developed as an information source for laboratory scientists, practicing physicians, and government agencies.
Research Institute of Fragrance Materials (RIFM) – Safety Assessments
Founded in 1996, RIFM was created to gather and analyze scientific data, engage in testing and evaluation, distribute information, cooperate with official agencies and to encourage uniform safety standards related to the use of fragrance ingredients. Over the years RIFM has evaluated thousands of flavor and fragrance materials and published peer-reviewed documents on their findings. The collection found in ToxPlanet comprises newer Safety Assessments published in the Open Access journal Food and Chemical Toxicology.
RTECS® – Registry of Toxic Effects of Chemical Substances
Previously maintained by NIOSH and now licensed through Dassault Systèmes BIOVIA, the Registry of Toxic Effects of Chemical Substances (RTECS®) database contains detailed profiles of over 150,000 chemical substances. Each profile provides relevant toxicological information, hazard classifications, international occupational exposure limits, regulatory information, occupational exposure survey data and references to toxicological reviews and NIOSH and OSHA analytical methods.
Shepard’s Catalog of Teratogenic Agents
Shepard’s, an essential resource for geneticists, teratologists, pharmacologists, and other health and safety professionals, presents information on more than 3,200 teratogenic agents, covering pharmaceuticals, chemicals, environmental pollutants, food additives, household products, viruses, genes, and maternal conditions.
Silent Spring Mammary Carcinogens Review Database
The Mammary Carcinogens Review database includes information on 216 chemicals that increased mammary gland tumors in animal studies conducted by the US National Toxicology Program (NTP) or included in the International Agency for Research on Cancer (IARC) Monographs, 11th Report on Carcinogens (11th ROC), Carcinogenic Potency Database (CPDB), or Chemical Carcinogenesis Research Information System (CCRIS) database. For each chemical, the database includes:
- carcinogenic potential
- ability to cause gene mutations
- exposure in the general population and for women at work
- other characteristics of chemical use, sources, and regulation.
SCENTbase is database of scent compound distributions among seed plants. At present, it contains c. 18500 records.
SPIN (Substances in Preparations In Nordic countries)
SPIN contains information on chemical substances from each of the Nordic product registers. The database is designed to provide the public with as much data as possible from the registers without disclosing confidential business information. The national product registers in Denmark, Finland, Norway and Sweden are unique and they contain valuable data concerning downstream uses of chemical substances in products on the national markets. Begun in 2000, SPIN is updated annually.
SOCOPSE (Source Control of Priority Substances in Europe)
The SOCOPSE (Source Control of Priority Substances in Europe) project was established to provide support and decision support tools for the implementation of the European Water Framework Directive (WFD) regarding priority substances. Eleven partners from seven European countries were involved in the development of a common approach and a Decision Support System (DSS). This collection includes the final chemical-specific substance reports produced by the Project.
Structure and Nomenclature Search System (SANSS)
SANSS (Structure and Nomenclature Search System) was initially developed by the U.S. National Institutes of Health (NIH), the U.S. Environmental Protection Agency (EPA) and the Chemical Information System. SANSS includes information from over 70 sources on nearly a million chemical names representing over 697,000 substances, including CAS Registry Numbers, structural diagrams, molecular formulas, systematic names, synonyms, and references to other sources of information. This database is no longer updated.
T3DB (Toxin and Toxin Target Database)
The Toxin and Toxin Target Database (T3DB), or, soon to be referred as, the Toxic Exposome Database, is a unique bioinformatics resource that combines detailed toxin data with comprehensive toxin target information. The database currently houses 3,678 toxins described by 41,602 synonyms, including pollutants, pesticides, drugs, and food toxins, which are linked to 2,073 corresponding toxin target records. Altogether there are 42,374 toxin, toxin target associations. Each toxin record (ToxCard) contains over 90 data fields and holds information such as chemical properties and descriptors, toxicity values, molecular and cellular interactions, and medical information. This information has been extracted from over 18,143 sources, which include other databases, government documents, books, and scientific literature.
TEDX List of Potential Endocrine Disruptors
The TEDX List of Potential Endocrine Disruptors is a database of chemicals with the potential to affect the endocrine system. No one has defined how much scientific evidence is “enough” to call a chemical an endocrine disruptor. The purpose of the TEDX List is to present the chemicals for which at least one peer-reviewed study has been published, so that scientists, regulators, advocates, and the public are better informed.
TERIS (Teratogen Information System)
TERIS is a database designed to assist physicians and other health and safety professionals in assessing the risks of possible teratogenic exposures in pregnant women. The database consists of a series of agent summaries, each of which is based on a thorough review of published clinical and experimental literature. Summaries may be accessed using either generic names or domestic or foreign proprietary names. Each summary includes a risk assessment derived by consensus of an Advisory Board comprising nationally-recognized authorities in clinical teratology.
Texas Commission on Environmental Quality (TCEQ) – Development Support Documents (DSDs) for Effects Screening Levels
A Development Support Document (DSD) summarizes how chemical-specific toxicity values were derived based on RG-442, Guidelines to Develop Effects Screening Levels, Reference Values, and Unit Risk Factors.
The Health Council of the Netherlands – Publications and Scientific Reports
The Health Council is an independent scientific advisory body tasked with providing the government and parliament with advice in the field of public health and health/healthcare research. Through its various committees, the Council publishes Advice, Opinions, and Scientific Reports on subjects requested by Ministers. This collection includes reports first published in the early nineties.
The MAK Collection for Occupational Health and Safety
The nearly 3,000 publications by the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK-Commission) provide essential information on hazardous compounds at the workplace. Threshold values and classifications for more than 1,000 substances are given, along with toxicological evaluations and recommended monitoring methods.
The MAK-Collection combines four individual series in two languages:
- MAK Value Documentations / Gesundheitsschädliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten und Einstufungen
- BAT Value Documentations / Biologische Arbeitsstoff-Toleranz-Werte, Expositionsäquivalente für krebserzeugende Arbeitsstoffe, Biologische Leitwerte und Biologische Arbeitsstoff-Referenzwerte. Arbeitsmedizinisch-toxikologische Begründungen
- Air Monitoring Methods / Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Luftanalysen
- Biomonitoring Methods / Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Analysen in biologischem Material
The Tropical Plant Database
The Tropical Plant Database is focused on delivering accurate information on the important plants of the Amazon Rainforest. Each plant database file contains taxonomy data, phytochemical information, ethnobotanical data, uses in traditional medicine systems, and clinical research (with links to clinical abstracts). Illustrated images are also included. Highly useful for both professional readers and readers new to medicinal plants, the information in the Tropical Plant Database is collected from many independent sources and publications.
The TOXLINE database is the National Library of Medicine’s (NLM) bibliographic database for toxicology, a varied science encompassing many disciplines. TOXLINE records provide bibliographic information covering the biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals. It contains over 3 million bibliographic citations, most with abstracts and/or indexing terms and CAS Registry Numbers. TOXLINE references are drawn from various sources grouped into two parts — TOXLINE Core and TOXLINE Special. ToxPlanet subscriptions include only the TOXLINE Special collection.
TOXLINE Special comprises:
Special journal and other research literature:
- Developmental and Reproductive Toxicology (DART®)
- International Labour Office (CIS)
Technical reports and research projects:
- Federal Research in Progress (FEDRIP)
- Toxic Substances Control Act Test Submissions (TSCATS)
- Toxicology Document and Data Depository (NTIS)
- Toxicology Research Projects (CRISP)
Archival collection (no longer being updated):
- Aneuploidy (ANEUPL)
- Environmental Mutagen Information Center File (EMIC)
- Environmental Teratology Information Center File (ETIC)
- Epidemiology Information System (EPIDEM)
- Hazardous Materials Technical Center (HMTC)
- Health Aspects of Pesticides Abstract Bulletin (HAPAB)
- NIOSHTIC (NIOSH)
- Pesticides Abstracts (PESTAB)
- Poisonous Plants Bibliography (PPBIB)
- Swedish National Chemicals Inspectorate (RISKLINE)
- Toxicological Aspects of Environmental Health (BIOSIS)
TradMPD - Traditional Medical & Pharmaceutical Database
The Traditional Medical & Pharmaceutical Database is the first repository of the experimental data of natural medicines used in Kampo (Traditional Japanese Medicine), including the genetic data of crude drugs, LC-MS profiling data, and biological activity data of crude drugs and Kampo formulas, etc. Most records include a diverse selection of information, such as image, parts used, constituents, pharmacological effects, indications, diseases, meridian/tropism, flavor, classification, medicinal effects, and more. The comprehensive data is useful for standardizing natural medicines and facilitating drug discovery.
U.S. Consumer Product Safety Commission (CPSC) – Technical Reports
These publications are the work product of the CPSC and/or its Chronic Hazard Advisory Panel (CHAP) addressing specific hazardous-substance issues affecting consumers.
U.S. Department of Agriculture – Agricultural Research Service Pesticide Properties Database (PPDB)
The ARS PPD is a compendium of chemical and physical properties of 334 widely used pesticides. Information included in the database focuses on 16 of the most important properties that affect pesticide transport and degradation characteristics. Its developers communicated directly with the manufacturers to obtain the original experimental data used to characterize the pesticide properties and fulfill requirements for federal and state regulations. The data are augmented with data from the scientific literature.
U.S. Fire Administration Hazardous Materials Guide for First Responders
Published by the U.S. Fire Administration, this database provides important information for the initial response to both transportation and fixed facility incidents involving hazardous materials. These documents are directed at First Responders trained at the Awareness and/or Operational levels.
U.S. Geological Survey Acute Toxicity Database
This database summarizes the results from aquatic acute toxicity tests conducted by the U.S.G.S. Columbia Environmental Research Center (CERC) located in Columbia, Missouri. The acute toxicity test provides a relative starting point for hazard assessment of contaminants and is required for federal chemical registration programs such as the Federal Insecticide Fungicide Rodenticide Act (PL 80-104) as amended by the Federal Environmental Pesticide Control Act of 1972 (7 U.S.C. 136-136y) and the Toxic Substances Control Act of 1976 (PL 94-469). The database was initially developed in 1986 by Foster L. Mayer (U.S. Fish and Wildlife Service) and Mark R. Ellersieck (University of Missouri, Columbia, MO) for 4,901 acute toxicity tests toxicity tests conducted by CERC since 1965 with 410 chemicals and 66 species of aquatic animals.
United Nations Environmental Program (UNEP) Screening Information Data Set (SIDS)
These publications are part of the series of OECD SIDS documents published by UNEP Chemicals in response to its mandate to facilitate the access to information needed for health and environmental risk assessment of chemicals. The documents contain the information gathered and an Initial Assessment performed under the framework of the OECD HPV Chemicals Programme. The information is provided as an indication of the current state of knowledge of these chemicals based on the Screening Information Data Set (SIDS), but does not presume to be comprehensive.
United Nations Rotterdam Convention Decision Guidance Documents (DGDs)
The Rotterdam Convention is a multilateral environmental agreement designed to promote shared responsibility and cooperative efforts among participants in the international trade of certain hazardous chemicals. Decision Guidance Documents (DGDs) are developed for each chemical listed in Annex III of the Convention and subject to the Prior Informed Consent (PIC) procedure. Each document provides background health and/or environmental reasons for regulatory actions to ban or severely restrict the chemical. These documents are available in English, Spanish, and French.
University of Hertfordshire – BioPesticide DataBase
The BPDB is a comprehensive database of data relating to pesticides derived from natural substances. Data includes Environmental Fate, Ecotoxicology, and Human Health.
University of Hertfordshire – Pesticide Properties Database
The PPDB is a comprehensive database of pesticide chemical identity, physicochemical, human health and ecotoxicological data. It has been developed by the Agriculture & Environment Research Unit (AERU) at the University of Hertfordshire for a variety of end users to support risk assessments and risk management. Data includes Environmental Fate, Ecotoxicology, and Human Health.
University of Hertfordshire – Veterinary Substances Database
The VSDB is a comprehensive database of physicochemical and toxicological data for veterinary substances. Data includes Environmental Fate, Ecotoxicology, and Human Health.
Workplace Hazardous Materials Information System (WHMIS)
Produced by Commission des normes, de l’équité, de la santé et de la sécurité du travail (CNESST), WHMIS is a Canada-wide system designed to give employers and workers information about hazardous materials used in the workplace. Hazardous materials covered by WHMIS are referred to as “controlled products”, and are grouped in categories of materials called “classes”.
Workplace Hazardous Materials Information System (WHMIS) Program on Safe Motherhood (PMSD)
WHMIS includes the Program on Safe Motherhood initiative with information on reproductive hazards associated with the hazardous substances included in WHMIS.
WHO Monographs on Selected Medicinal Plants
A series of volumes, the WHO monographs on selected medicinal plants aims to: provide scientific information on the safety, efficacy, and quality control of widely used medicinal plants; provide models to assist Member States in developing their own monographs or formularies for these and other herbal medicines; and facilitate information exchange among Member States. WHO monographs, however, are not pharmacopoeial monographs, rather they are comprehensive scientific references for drug regulatory authorities, physicians, traditional health practitioners, pharmacists, manufacturers, research scientists and the general public.
Each monograph follows a standard format with information presented in two parts followed by a reference list. The first part presents pharmacopoeial summaries for quality assurance. The second part includes sections on medicinal uses, pharmacology, safety issues, and dosage forms. The descriptions under the medicinal uses section merely represent, for purposes of information exchange, the systematic collection of scientific information available at the time of each volume’s preparation and should not be taken as having WHO’s official endorsement or approval.
Volume 1 contains 28 monographs published in 1999. Volume 2, published in 2003 includes 30 monographs. Volume 3 in this series was published in 2007 and includes 31 monographs. Volume 4, which was published in 2009, includes 28 monographs.
Each volume after Volume 1 has a general technical notice and two cumulative indexes to facilitate referencing; one lists the monographs in alphabetical order by plant name and the other according to the plant material of interest.
WHO/FAO Joint Expert Committee on Food Additives (JECFA) Monographs and Evaluation Summaries
Toxicological evaluations of food additives and contaminants and of residues of veterinary drugs in food, produced by the Joint WHO/FAO Expert Committee on Food Additives JECFA, are used by the Codex Alimentarius Commission and national governments to set international food standards and safe levels for protection of the consumer. The monographs, prepared by scientific experts and peer reviewed at the JECFA meetings, provide the toxicological information upon which the JECFA makes its evaluations.
WHO/FAO Joint Meeting on Pesticide Residues (JMPR) Monographs
Toxicological evaluations of pesticides, produced by the WHO/FAO Joint Meeting on Pesticide Residues (JMPR), are used by the Codex Alimentarius Commission and national governments to set international food standards and safe levels for protection of the consumer. The monographs, prepared by scientific experts and peer reviewed at the JMPR meetings, provide the toxicological information upon which the JMPR makes its evaluations.
WHO/FAO Pesticide Data Sheets (PDSs)
Prepared by WHO in collaboration with FAO, PDSs contain basic toxicological information on individual pesticides and basic information for the safe use of pesticides. Priority for issue of PDSs is given to substances having a wide use in public health programmes and/or in agriculture, or having a high or an unusual toxicity record. The data sheets are prepared by scientific experts and peer reviewed. The comments of industry are provided through the industrial association, GIFAP. The data sheets are revised from time to time as required.