This Is the Best Solution for Overhauling Read-Across Functionality

In the realm of toxicology, there are avid proponents and opponents of the read-across method. Researchers know this alternative to direct chemical testing, but how can this process improve? We’ve compiled some of the ways in which intuitive databases can remedy the data gaps involved in its use.

Scientific advancements result in a constant flow of new products and materials into industries of all kinds. With those advancements come alternatives to previously accepted uses of scientific methods in the real world. If you and your team are interested in transforming the functionality of methods like read-across, download our free Whitepaper! It will guide you through fresh ways to get the information you need in the most efficient way possible.

The Best Solution for Overhauling Read-Across Functionality

Read-Across and Big Data

In the safety sciences, information technology has made it easy to reveal patterns and associations in data sets. We do this in three ways: compiling sets of existing data, using omics technology, and high-throughput laboratory testing. These approaches pair toxicology with big data. The challenge researchers face is making sense of these data efficiently.

Read-across is the use of a data-rich substance as an analog for a data-poor substance. Read-across applies predominantly in vivo test data, where it has gained significant momentum. The read-across method is an alternative to direct testing that serves as a viable solution for filling data gaps. Big data are catalysts for discovering similar substances and ensuring that available data reach their full potential. In these circumstances, structurally and biologically similar properties create the confidence science professionals need to predict toxic properties.

The Future of Read-Across

The problem: An estimated 80,000 identified chemicals circulate commercially, and only 10,000 feature robust, available literature. Both read-across and standard animal testing combat this issue, but both are more complicated than necessary. Animal testing, of course, is a hot-button issue because of its price tag for companies and perceived harm to living organisms. Read-across is an innovative method that is cheaper than standard laboratory testing, but currently requires a significant amount of research time and a big margin of error to utilize. Fortunately, as advancements occur in information technology, intuitive database subscriptions are making it easier than ever to maximize the output of the read-across method.

Receive a 2-Week Free Trial of ToxPlanet

ToxPlanet’s decision-support solutions can be combined with the read-across method to create an efficient way to verify chemical properties. Our products comprise a collection of discipline-focused databases that can be purchased separately or together as one robust, comprehensive resource. Our innovative databases cover data pertaining to hazardous chemicals, substance regulations, reproductive risk, and pharmaceutical data.

If you and your team wish to deepen and simplify chemical research processes, try our 2-week Free Trial of ToxPlanet today! For 15 days, you’ll experience the breadth and depth of our useful content and the ease of being a ToxPlanet subscriber. You’ll also receive access to every database, document, and update.


Ready to transform the read-across method into something that is easier to implement? Request your free trial today!